Scientists report two life-saving treatments for Ebola

Thursday, August 15, 2019

On Monday morning, Director Anthony Fauci of the United States National Institute of Allergy and Infectious Diseases (NIAID), announced a trial of four possible Ebola drugs was stopped early because two of them had already shown considerable progress in treating the disease and saving the lives of those infected. Ebola virus disease (EVD) is a hemorrhagic fever with a high mortality rate and spreads via human-to-human contact.

The PALM trial, for the Swahili phrase pamoja tulinde maisha or “together save lives,” began last November and collected data from 499 patients from the towns of Beni, Butembo, Mangina, and Katwa in the Democratic Republic of the Congo, which has suffered an Ebola outbreak for roughly the past year.

Professor Jean-Jacques Muyembe, Director General of the DRC’s Institut National de Recherche Biomédicale that monitored the trial, said, “From now on, we will no longer say that Ebola is incurable[.]” He went on to say thousands of deaths could be prevented.

While one experimental vaccine appears able to reduce Ebola mortality, up until now, no drugs have been clearly demonstrated suitable for treating existing infection. One antibody cocktail, ZMapp, initially showed promise in the field, but formal studies indicated it had less benefit than sought in preventing death. In the PALM trial, ZMapp served as a control, meaning scientists used it as a baseline and compared the three other treatments to it.

The other three treatments were remdesivir, an antiviral drug; mAb114, a monoclonal antibody first isolated from human survivors of an outbreak in Kikwit in 1995, now produced by the Florida company Ridgeback Biotherapeutics; and REGN-EB3, a cocktail of three monoclonal antibodies from Ebola-infected laboratory mice whose immune systems had been altered to be similar to humans’.

The overall mortality rates were 49% for patients treated with ZMapp, 53% for remdesivir, 29% for REGN-EB3, and 34% for mAb114, but patients treatment early with low viral loads had a death rate of only 6% to 11% when treated with REGN-EB3 or mAb114.

Mike Ryan of the World Health Organization (WHO) told the press the new drugs were only part of the solution: “What will stop Ebola, under professor Muyembe’s leadership and that of the government of the DRC, is good surveillance, good infection prevention and control, good community engagement, excellent vaccinations, and the use of these therapeutics in the most effective way possible.”

Past EVD outbreak mortality rates have been at least 25%, as high as 90%, and averaged around 50% according to WHO’s statistics. According to Muyembe, many people do not seek treatment because they see their friends and relatives die after entering a care facility. “Now that 90% of their patients can go into the treatment center and come out completely cured,” he told the press, “they will start believing it and building trust in the population and community[.]”

Per the WHO’s Monitored Emergency Use of Unregistered and Investigational Interventions framework, all treatment centers in the DRC are to be permitted to administer mAb114 and REGN-EB3 to patients, even though research into the two treatments is not yet complete, and ZMapp and remdesivir are to be retired. A follow-on study, to be performed in the same four treatment centers as PALM, is to involve randomly assigning patients either a mAb114 or REGN-EB3 regimen.

In the DRC’s current Ebola outbreak, two thirds of those known to be infected with Ebola, over 1800 people, have died.

Ontario Votes 2007: Interview with Freedom Party candidate Wayne Simmons, Don Valley East

Wednesday, October 3, 2007

Wayne Simmons is running for the Freedom Party in the Ontario provincial election, in the Don Valley East riding. Wikinews’ Nick Moreau interviewed him regarding his values, his experience, and his campaign.

Wayne did not answer “Of the decisions made by Ontario’s 38th Legislative Assembly, which was the most beneficial to your this electoral district? To the province as a whole? Which was least beneficial, or even harmful, to your this riding? To the province as a whole?”

Stay tuned for further interviews; every candidate from every party is eligible, and will be contacted. Expect interviews from Liberals, Progressive Conservatives, New Democratic Party members, Ontario Greens, as well as members from the Family Coalition, Freedom, Communist, Libertarian, and Confederation of Regions parties, as well as independents.

Washer And Washing Machine Cycles Of Operation

By Richard Caldwell

A typical wash cycle of a typical agitator-type washing machine begins with a fill period of anywhere from 2 to 5 min. depending on the water level selected and the water pressure. Maytag, Whirlpool, Kenmore (Sears), Frigidaire, and GE may have minor capacity differences and thus time differences. The washing period, which will be for anywhere from 2 to 12 minutes, also depends on the setting the operator has selected. After the wash cycle is completed, the machine pauses for 1 min for the purpose of reversing motor rotation. After the 1-min pause, water is pumped from the spin basket and the outer tub. The spin basket does not spin during this operation, although, if there is no clothing or very little clothing in the spin basket, there is a tendency for it to move slightly. The washer agitator may also move very slightly, and this must not be mistaken for a fault in the washer. The motion of both the basket and the agitator will not occur in cases where there is a least a minimum amount of clothing in the basket.

The following is the general cycle of operation, with the approximate time used in the various states:

Wash fill – 3 to 4 minutes

Wash – 1 to 15 minutes

Spin – 2 to 3 minutes

[youtube]http://www.youtube.com/watch?v=IRpHPK5eTL0[/youtube]

Rinse Fill 3 to 4 minutes

Rinses 2 to 3 minutes

Spin Dry 3 to 5 minutes

Total Time 14 to 34 minutes

This is not exact cycle and like I said above, there are minor differences between such brands as Whirlpool, Kenmore (Sears), Maytag, GE, and others. The time for one complete cycle may range from as little as 14 minutes to as long as 34 min, depending on the particular machine and length of the washer period which the user selects.

During the washer pump out period, water enters the spin basket and removes all suds from the outer tub as well as the spin basket and clothes load. By the end of the pump out period, all water has been removed from the spin basket and the outer tub. After the pump out period, the spin basket spins under power for a period of minute. After this time, power to the motor is turned off, and the basket is free to coast. The spin basket coasts through the next 2 min. during which time rinse water enters the washer basket and pump still operates.

The initial power spin and the subsequent coasting of the spin basket, together with the spin-spray water entering the clothes, have a tendency to wash any lighter-than-water soil from the fabric and flush it away from the clothing. The washer spin basket is operating only at slow speed at this time; therefore, the clothing is not packed so tightly that a scum or lighter-than-water soil will be trapped.

After the initial spin rinse, the normal extraction spin of our typical washer occurs for a period of 2 minutes, after which the spin basket wills with water for a period of not less than 2 minutes and not more than 4 min, depending upon the original setting of the water level switch. The difference between the initial fill and the rinse fill comes about through the fact that the clothes in the spin basket contain some water which is not found in the original load.

After our typical washer is filled with rinse water, there is a 4 min period of agitated deep-wave rinse. The 1 min pause and 2 min pump out periods are repeated, after which the spin basket operates for a total of 7 min to extract water from the clothes. After the first 3/4 min, a1 /4 min spin spray occurs for an additional fresh-water rinsing. Please understand the cycle of operations, because if washers pause for 1 min and you do not realize the reason for it, you may have already have called the service technician before the machine starts again. The cycle times of various operations of the washers are given in the service manuals.

Please use this as a basic guide to understand the basic operating principles of the top-load automatic washing machine. Once again, there are slight variations between Maytag, Whirlpool, and Kenmore (Sears), so special considerations may be necessary.

About the Author: For all your Boise Appliance Repair needs please visit Western Appliance Repair at

Boise Appliance Repair

We provide all your Appliance Repair needs in Boise and Eagle Idaho. Choose

KitchenAid Repair Boise

Source:

isnare.com

Permanent Link:

isnare.com/?aid=718058&ca=Home+Management

Jersey child abuse case ‘was not covered up’

Tuesday, February 26, 2008

Frank Walker, the chief minister of Jersey, a United Kingdom Crown dependency off the coast of Normandy, France, denies that there was a cover up after a child’s remains were found.

The allegations of a cover-up stem from statements by Stuart Syvret. Syvret, the former Minister for Health and Social Services for Jersey, said that “It’s a continuum that we see. It’s a culture of cover-up and concealment and tragically the recent evidence is just the latest manifestation of that.”

It has come to light that Edward Paisnel, a notorious pedophile, used to visit the Haut de la Garenne children’s home dressed as Father Christmas. Paisnel in 1971, was given a sentence of 30 years for 13 counts of assault, rape and sodomy.

Syvret says he was dismissed from his ministerial position after highlighting the “torture” of 11 to 16-year-olds in the island’s care homes. He claimed he was “sacked for whistleblowing”.

Police are currently investigating twenty-seven cases of child abuse on the island and recently discovered the body of one child at a care home Haut de la Garenne in St. Martin, and with a potential six sites in the area where more bodies may be located. The home was closed in 1986 and since 2003 it has served as a youth hostel.

Jersey’s deputy police chief, Lenny Harper said “Part of the inquiry will be the fact that a lot of the victims tried to report their assaults but for some reason or another they were not dealt with as they should be.”

Harper added that “no evidence of a cover-up of any Jersey government” has been found. “We are looking at allegations that a number of agencies didn’t deal with things as perhaps they should.”

Syvret has encouraged the government of the United Kingdom to assign independent judges to oversee any cases that result from the investigations.

Builders originally uncovered a body at the care home in 2003 but it was only since an operation investigate child abuse started in 2006 that progress has been made. An ex-minister of the States of Jersey, the parliament of the island, has criticised the handling of the case, stating that abuse cases were mishandled.

Walker told senators that all necessary resources would be use to find the abusers. “None of us imagined that children in Jersey could be abused and mistreated in the way that is being suggested,” the BBC have quoted him as saying. “I express my shock and horror that these things have apparently happened within our island.”

Specialist police from the United Kingdom have been investigating after an enquiry turned up 140 sources verifying the claims of abuse.

British MP David Cairns dies aged 44

Wednesday, May 11, 2011

British MP David Cairns has died at the age of 44. Cairns died at the University College London Hospital where he was admitted to intensive care in March suffering from acute pancreatitis. He had represented the constituency of Greenock and Inverclyde in Scotland since 2001 as a member of the Labour party.

Labour issued a statement saying “It is with great regret that we have to announce that David Cairns, member of parliament for Inverclyde, passed away at 2300 last night at the Royal Free, London. David had been suffering from acute pancreatitis after he was admitted as an emergency patient eight weeks ago. Our thoughts are with his partner Dermot, his father John and his brother Billy and all his many friends and family.” The statement added “David’s untimely death is a huge loss to parliament and politics in this country.”

Scottish First Minister Alex Salmond called Cairns — a former Scotland Office minister — “clearly a dedicated and principled parliamentarian, and an effective representative of his constituents, who carried respect across the political spectrum and far beyond.” Scottish Secretary Michael Moore, a Liberal Democrat, said “David contributed a huge amount to Scottish political life and was a decent, intelligent and warm figure who was liked and respected across political divides.”

Cairns’s Conservative successor to the Scotland Office job said Cairns “was a truly decent man, who worked tirelessly for his constituents and for the interests of Scotland.”

Current Labour leader Ed Miliband also released a statement, saying “David will be missed beyond measure as a former minister, as an MP, as a friend and a colleague by many people.” Former prime minister Tony Blair paid tribute to him by saying “David’s life was dedicated to public service. He was a committed and conscientious constituency MP, an excellent government minister and a passionate campaigner for social justice, equality and opportunity.”

Cairns, who was a Roman Catholic priest before entering politics, was only allowed to become an MP when a new law was passed. Before 2001 a 19th-century law had stated that former Catholic priests were not allowed to stand as members of parliament. It was only when The House of Commons (Removal of Clergy Disqualification) Act 2001 was brought into force that he could stand for parliament.

Cairns resigned during Gordon Brown’s term as Prime Minister over disputes about Brown’s position in 2008 but was re-elected at the last general election.

Due to Cairns’s death a by-election will have to be held to decide who will become his successor.

Used Forklifts: Why Are They So Much In Demand?

Used Forklifts: Why Are They So Much In Demand?

by

seeyut jone

If there is anything that is patronized heavily across the myriad range of industries that we have today then, it is definitely the used forklifts. It is an undeniable fact that a forklift comes in at a premium price and obviously when one opts for a big brand in the segment, they need to put down a lot of money.The used forklifts save all such pain for the industry owner. Needless to mention, the used ones come in at lesser price when compared to the brand new counterparts. A sheer comparison of the price tags would elucidate on the price difference between the used and the new ones.

[youtube]http://www.youtube.com/watch?v=PdoQTBNZKFU[/youtube]

Buying brand new forklifts involves a lot of money for the companies and when they are looking out for cutting down on costs, investing in used forklifts seems to be the best option. Another major reason why these used ones are the most preferred ones is that these machines are highly reliable. The used ones are just as efficient as the new ones and in majority of the cases do not call for huge maintenance programs. A keener look into the forklifts market will reveal that there are a number of distributors who are now-a-days selling used forklifts or offering equipment hire service too. Whether it is investing in used forklifts or choosing the equipment hire option, the business owner can save on a lot of money as it does not call for spending more on buying the machine. It is for their high utility value that the used forklifts are so much in demand and have become the most sought after machines. Invest in one used forklift and get it refurbished or buy a refurbished one and you can have it for years to come. Basing on the kind of requirement and usage that is at hand one may weigh the pros and cons of each of the options and then take an informed decision. Biondo Rentals claim to be the specialists in the area of forklift attachments and used forklifts segment.

Whether it is goods to be moved or a forklift parts for a specific job application, we advise the client of the best way to carry out the works and also can work in with their budgets.New or

used lift

truck buyers and new or used forklift sellers can locate used forklifts for sale, including forklift components, fork lift truck attachments.

Article Source:

ArticleRich.com

Southern Ocean whale slaughter to resume

Tuesday, January 3, 2006

The international environmental organisation, Greenpeace, have been shadowing a Japanese whaling fleet currently operating in the Southern Ocean in Australian Antarctic Territory. They claim a minor victory against the six-vessel fleet, saying no whales have been killed since Christmas Eve. However they expect a resumption of whaling and protest activity soon.

Greenpeace has two ships, MV Esperanza and MV Arctic Sunrise, active near Antarctica, in an effort to disrupt the whalers, who intend on slaughtering over 900 Minke whales and 10 Fin whales in the region this summer. The activists aim to stop the Japanese whaling fleet as it tries to catch nearly 1000 whales for what is claimed to be scientific research.

Greenpeace chief Steve Shallhorn states that the protesters have chased the six-ship fleet northwards, with the vessels now away from the designated whaling zone. Greenpeace plan to maintain their efforts to keep the whalers in the public eye.

“What the fleet is doing is trying to outrun Greenpeace so that it can sneak back into the whaling grounds and resume the kill,” he said. “And for that very reason, we’re doing our very best and are succeeding in keeping up with the factory whaling ship. We are certain that they do not want any further publicity.”

He said Greenpeace will continue its high-speed tailing for as long as it takes. “We’re capable of staying out there for many more weeks,” he said. “The [Japanese] fleet is clearly embarrassed by having their actions exposed to the world, since the spotlight on their activities shows what it really is – commercial whaling with a very thin disguise.”

The whalers have been unable to kill any whales since Christmas Eve due to poor weather and harassment by Greenpeace vessels, and the Washington-based Sea Shepherd ship, RV Farley Mowat. The Sea Shepherd is operating independently of Greenpeace but say they are working towards a common objective – “the shutting down of illegal whaling in the Southern Ocean.”

Greenpeace expedition leader Shane Rattenbury says the whalers have a season of about 100 days. “Their quota is 945 whales. If you lose, say, 10 per cent of those through bad weather, they’ve got an average they need to catch of 10 a day and it’s gone 10 days now without having any whales,” he said. “That starts to add up pretty quickly. They’re under a bit of pressure to get on with the business.”

Japan’s Institute for Cetacean Research have rejected the claims made by Sea Shepherd, that Japanese warship was being sent to Antarctica to protect the fleet against the activists.

The Japanese institute spokesman condemned Sea Shepherd over the claim by Farley Mowat captain Paul Watson, who called on the Australian Government to keep the peace.File:Greenpeace Vessels Esperanza and Arctic Sun.jpg

Sea Shepherd had requested the presence of the Australian navy to monitor events in the Southern Ocean. However, Australia’s environment minister, Senator Ian Campbell, said that Sea Shepherd’s threats to attack the fleet “risk setting back the cause of whale conservation many years”.

Capt Watson said yesterday: “Stop threatening us, Mr Campbell, and charge us if you believe we are acting unlawfully. Stop posing for the Japanese [who] are in blatant violation of international conservation laws.”

Japan’s Fisheries Agency, which conducts the whaling, said the claim was a tactic by Sea Shepherd to try to raise the stakes for extra publicity.

“This is why the environmentalists’ campaign in the Antarctic is a PR stunt: every time they get some media coverage there’s always some member not too far away asking the public for money,” an agency spokesman said in a statement. “Only this time, it completely backfired and now people will question what these groups say.”

The spokesman had no response to Greenpeace’s claim that another vessel had joined the whaling fleet and was refuelling the ships within the boundary of the Antarctic Treaty’s nature reserve.

Mr Rattenbury said the 57 activists and crew aboard the Greenpeace ships were in good health following a quiet New Year’s Day celebration on deck under a midnight sun.

Wikinews Australia has in-depth coverage of this issue: Southern Ocean whaling season (2005-2006)

He said his ships were not in contact with the Farley Mowat, which is believed to be closer to the Antarctic ice shelf. The Farley Mowat’s weblog quoted ship captain Paul Watson as saying the Sea Shepherd group had no conflict with Greenpeace, despite earlier British media assertions.

“As far as I am concerned both Sea Shepherd and Greenpeace are working towards a common objective – the shutting down of illegal whaling in the Southern Ocean,” said Paul Watson.

Greenpeace believes the fleet killed at least 25 whales from the time it contacted the whalers just before Christmas.

New Zealand begins process to consider changing national flag design

Thursday, May 7, 2015

On Tuesday, the New Zealand government announced the start of a public process to suggest designs for a new national flag, and determine whether their citizens would prefer a different national flag over the current one.

The current New Zealand flag is partially based on the United Kingdom’s flag; the new one would be unique to New Zealand. The government’s Flag Consideration Project has planned a number of conferences and roadshows as part of this process, with the first meeting set to take place in Christchurch on May 16. According to the New Zealand Herald, Emeritus Professor John Burrows, the chairman of the project’s panel of twelve, said New Zealand’s flag has never before been open to public choice.

Professor Burrows also said resources and kits would be accessible for schools and communities, “For example, schools can run their own flag discussions and referendums to mirror the formal process as part of their own learning exercise”. People were encouraged to submit their designs online at www.flag.govt.nz and suggest what the flag should mean on www.standfor.co.nz. Names of participants would be engraved, at their option, on a flag pole monument to be built in the nation’s capital, Wellington.

New Zealand’s Prime Minister John Key said he believes redesigning the flag now has a “strong rationale”. Mr Key promoted the campaign for a unique New Zealand flag on Waitangi Day — February 6 — this year. Of the public process, he said, “In the end I’ll have one vote in each referendum just like every other New Zealander on the electoral roll”.

The New Zealand government intends to hold two referendums to reach a verdict on the flag, at an estimated cost of NZ$26 million, although a recent poll found only a quarter of citizens favoured changing the flag. This is a decrease from the year before, when it was forty percent. The first referendum is to be held from November 20 to December 11, selecting a single new flag design out of about four finalists. Voters would then choose between the new flag and their current flag early in 2016.

Election in Moldova instigates rioting mob demanding recount

Thursday, April 9, 2009

Protests which began Monday escalated to a riot on Wednesday consisting of over 10,000 people in Chi?in?u, the capital of Moldova, protesting the results of Sunday’s 2009 Moldovan parliamentary election, which showed an apparent, narrow victory for the Communist Party (Partidul Comuni?tilor din Republica Moldova, PCRM). Demonstrators claim the victory was the result of electoral fraud.

The demonstration escalated to a “flash mob” of between 10,000 to 15,000 communicating via online tools like email, micro-blogging tool Twitter, and social-networking website Facebook. “We sent messages on Twitter but didn’t expect 15,000 people to join in. At the most we expected 1,000”, said Oleg Brega of the activist group Hyde Park.

Police deployed tear gas and water cannons, and fired blanks into the crowd. The rioters threw stones at the riot police and took control of the parliament building and presidential office. A bonfire was built out of parliamentary furniture and all windows below the 7th floor were broken.

Approximately one hundred protesters and 170 police officers are reported as injured. There have been conflicting reports as to whether a female protester died during the altercation.

193 protesters “have been charged with looting, hooliganism, robbery and assault,” said an Interior Ministry spokesperson. This announcement sparked another protest by those demanding the release for those detained.

There is wide speculation about who was to blame for the rioting.

President Vladimir Voronin has expelled the Romanian ambassador from Moldova, blaming Romania for the violent protests. “We know that certain political forces in Romania are behind this unrest. The Romanian flags fixed on the government buildings in Chisinau attest to this” said Voronin. “Romania is involved in everything that has happened.“ Voronin also blamed the protests on opposition leaders who used violence to seize power, and has described the event as a coup d’état.

Protesters initially insisted on a recount of the election results and are now calling for a new vote, which has been rejected by the government. Rioters were also demanding unification between Moldova and Romania. “In the air, there was a strong expectation of change, but that did not happen”, said OSCE spokesman Matti Sidoroff.File:Dorin Chirtoaca.jpg

“The elections were fraudulent, there was multiple voting” accused Chi?in?u mayor Dorin Chirtoac? of the Liberal Party. “It’s impossible that every second person in Moldova voted for the Communists. However, we believe the riots were a provocation and we are now trying to reconcile the crowd. Leaders of all opposition parties are at the scene,” said Larissa Manole of the Liberal Democratic Party of Moldova.

The Organisation for Security and Cooperation in Europe (OSCE) proclaimed the PCRM to have won 61 seats in initial counts, enough to guarantee a third term in power for Voronin, who has held the position since 2001. But the Central Election Commission has received evidence of election violations, according to RIA Novosti, and upon recounts conducted of disputed polls, the commission reported that the Communists achieved 49.48% of the Moldovian vote, giving them 60 parliamentary seats — one short of the total needed to win the presidential election. “The electoral commission also granted opposition parties permission to check voter lists, fulfilling one of their chief demands,” said Yuri Ciocan, Central Election Commission secretary.

Voronin will step down in May, however his party could elect a successor with 61 parliamentary seats without any votes from outside parties as well as amend the Constitution. With the PCRM garnering 60 seats, the opposition will have a voice in the presidential election for a new successor.

The western part of Moldova was a part of Romania from the Romania’s independence until the region was detached by the USSR in 1940 to form the Moldavian Soviet Socialist Republic. On independence in 1990 the country sought union with Romania but the eastern, Russian- and Ukrainian-inhabited areas of the country declared themselves independent from Moldova and formed the state of Transnistria and movement toward union was halted.

Moldova is Europe’s poorest country, where average income is less than $250 (£168) a month. The country’s neighbours are Romania and Ukraine. Romania is a European Union (EU) state.